BCHE and Fat Metabolism

Butyrylcholinesterase and lipid metabolism: Possible dual role in metabolic disorders – ScienceDirect

In the complex world of our body’s inner workings, a lesser-known hero called Butyrylcholinesterase (BChE) is taking the spotlight. Except no one is talking about it!

Initially recognized for breaking down specific substances, this enzyme is found in important organs like the liver, blood, and brain. Recent scientific discoveries, however, reveal that BChE might have a broader role in managing fats, or lipids, in our bodies.

Exploring BChE and Lipid Metabolism:

The study looks into the intricate connection between BChE and lipid metabolism. When our body’s balance is disrupted, like in cases of obesity or high blood fat levels, BChE appears to become more active, acting as a crucial signal in response to these irregularities.

Beyond the “Fat Alarm”:

Contrary to just being a “fat alarm,” BChE is more complex. It also helps in making carriers called lipoproteins, which transport fats in our body, through the blood and lymphatic system. This discovery makes BChE even more important in managing fats than we thought.

Genetic variations in the BCHE gene may also impact BChE’s role in lipid metabolism.

A Two-Sided Narrative:

Scientists are trying to figure out whether BChE causes problems with fat in our bodies or if it’s trying to fix the problem. The ongoing research aims to understand whether BChE is a cause or a result of these fat-related issues.

The body’s responses to challenges are intricate, and what might initially seem like a problem might, in fact, be an attempt to restore balance or address an underlying issue. An example of this is cholesterol. We were told not to eat foods with cholesterol like eggs and red meat, or it would clog our arteries. In reality, cholesterol is trying to fix the problem caused by sugar and carbs, it’s not the cause…yet still to this day, with this new information, doctors are still pushing cholesterol lowering drugs, and telling us to not eat red meat and eggs.

Additional Insights into BCHE:

  • Studies show that mice without BCHE tend to become obese, highlighting the enzyme’s influence on body weight regulation.
  • BCHE plays a crucial role in breaking down ghrelin, the hunger hormone, revealing its role in controlling appetite.
  • Experiments with rats injected with ghrelin show a tendency for obesity, highlighting BCHE’s involvement in weight management.
  • The enzyme also helps protect acetylcholinesterase, the enzyme needed to maintain balance in acetylcholine, a vital neurotransmitter.
  • BCHE showcases its detoxification abilities by helping eliminate pesticides, herbicides, and toxic alkaloids present in nightshade foods.
  • Exposure to these toxins decreases BCHE activity.

My personal experience with a BCHE Deficiency:

I’ve always struggled with losing weight, and I experienced a lot of “food noise”. Food noise means that I was always hungry, even when I had just eaten, making focusing on work, very difficult. When I finally started eating to support BCHE, all of that changed.

The first thing I did was remove nightshade foods and this turned off a lot of the food noise. Nightshades are cholinesterase inhibitors. Then later I removed all other cholinesterase inhibitor foods, plant protein, and oxalates. Protein is reported to increase BCHE, but so far pea protein is reported to have the opposite effect. Instead, I switched to the Carnivore diet and greatly increased my consumption of red meat and eggs. The weight melted off without effort and without exercise. The food noise was completely gone, and so were all my carb and sugar cravings. It brought balance back to my brain and my body. Eating to support BCHE proved to be very powerful in my own case.


This study helps us understand more about how our body works with fats and how BChE might be involved. It’s like a detective story where scientists are trying to solve the mystery of BChE’s role in our health. This newfound knowledge could be crucial in finding ways to keep our bodies healthy and manage conditions like obesity and high blood fat levels.

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